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Evolutionary Medical Genomics Doctoral Network

Project description

Evolutionary genomics for next-generation medicine

Many of today’s greatest health challenges are driven by evolution. This needs to be considered when developing treatments for cancer resistance, ageing, and antibiotic resistance. Supported by the Marie Skłodowska-Curie Actions programme, the EvoMG-DN project will train a new generation of interdisciplinary researchers. The project aims to explore how evolutionary insights guide adaptive cancer therapies, improve understanding of ageing, and tackle pathogen resistance. Using tools such as comparative genomics, machine learning, and unconventional model organisms, EvoMG-DN bridges biology, medicine, and data science. Beyond research, it provides structured training and mentoring, preparing doctoral candidates to translate evolutionary insights into healthcare solutions.

Objective

The Evolutionary Medical Genomics Doctoral Network (EvoMG-DN) pioneers an integrative approach combining Evolutionary Medicine and Medical Genomics to address critical health challenges. By combining evolutionary insights with state-of-the-art genomic tools, EvoMG-DN seeks to establish EvoMG as a structured and impactful discipline in Europe. The network aims to train the next generation of interdisciplinary researchers to unlock the full potential of evolutionary genomic approaches in healthcare.

EvoMG-DN pursues three overarching objectives: (i) foster interdisciplinary synergy by uniting EvoMG researchers from diverse fields to catalyze innovation in methodologies and tools; (ii) create a cohesive training framework, equipping doctoral candidates (DCs) with expertise in EvoMG applications through structured training and collaboration; and (iii) advance evolution-informed clinical applications, such as adaptive cancer therapies.

The research program is organized into three scientific work packages: WP1 explores evolutionary insights into ageing and age-related diseases; WP2 focuses on tumor evolution and acquisition of resistance in cancer therapies; and WP3 addresses pathogen evolution, antibiotic resistance and interactions with the immune system. These are underpinned by core methodological pillars, which include comparative functional genomics, genetic diversity analysis, mathematical modeling and machine learning, and the use of unconventional model organisms.

Through interdisciplinary secondments, tailored mentoring, and advanced training modules, EvoMG-DN empowers DCs to bridge disciplines and develop actionable solutions to global health challenges. By formalizing EvoMG methodologies and advancing clinical applications, EvoMG-DN aims to solidify Europe’s leadership in biomedical research and deliver long-lasting societal impact.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

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(opens in new window) HORIZON-MSCA-2024-DN-01

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Coordinator

FUNDACIO CENTRE DE REGULACIO GENOMICA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 564 376,32
Address
CARRER DOCTOR AIGUADER 88
08003 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
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Total cost

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Participants (10)

Partners (11)

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