Project description
Making medical devices safer by fighting infections from the inside out
For patients relying on catheters or heart implants, infection is a constant and often invisible threat. These indwelling device-associated infections can be life-threatening and are difficult to treat, as bacteria form protective biofilms that resist antibiotics. Despite existing antimicrobial coatings, many devices still leave patients vulnerable. Supported by the Marie Skłodowska-Curie Actions programme, the iSTRIDE project will train young scientists to develop better diagnostics and more effective antimicrobial solutions. Combining expertise from hospitals, universities and industry, iSTRIDE offers interdisciplinary PhD training focused on real clinical needs. It will also merge microbiology, materials science and diagnostic technology to make medical devices safer, and save lives in the process.
Objective
iSTRIDE will educate young scientists to develop innovative solutions to reduce the high incidence and mortality of Indwelling Device Associated Infections (IDAIs). IDAIs can be associated with urinary and intravenous catheters and cardiovascular devices, and result from microbial transfer and biofilm formation on the device surface. The clinical burden of IDAIs is significant and can be life threatening, while difficult to diagnose and to treat due to the high antibiotic tolerance of biofilm cells. While there are antimicrobial device coatings available, their effectiveness is limited.
iSTRIDE’s first objective is to provide a platform for young scientists to pursue a highly inter disciplinary PhD training focused on translational skills towards a career in biomedical research and medical technology development. iSTRIDE’s second objective is to address the challenges of IDAIs by developing novel antimicrobial coatings for indwelling devices and improved diagnostic tools to monitor their efficacy, by building on realistic IDAI models that represent all aspects of infection.
iSTRIDE relies on a carefully selected inter-sectoral project consortium (six hospitals, one research institute, seven universities and three industrial partners) that crosses disciplinary borders (microbiology, material sciences and diagnostic technology). The iSTRIDE training programme is structured so that each DC will work on the interface of at least two of these disciplines via the host lab and secondments. The consortium includes expertise from the clinical, engineering, polymer chemistry, microbiology, soft matter engineering and cell biology domains, and involves companies active in advanced diagnostics and the medical device industry. Partner organisations from different regions of Europe will provide clinical samples, and each DC will experience a secondment at a hospital to gain awareness of the clinical context of their work.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- natural sciences chemical sciences polymer sciences
- medical and health sciences basic medicine pathology
- engineering and technology medical engineering medical laboratory technology diagnostic technologies
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3000 Leuven
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.