Objective
Trained immunity (TRIM) is a novel concept in immunology. Maladaptive TRIM offers a framework to understand how innate immune memory drives systemic inflammatory changes and inter-organ communication, leading to secondary tissue dysfunction. Initially identified in infection, TRIM has now been linked to sterile injuries like myocardial infarction (MI) and ischemic stroke. These injuries induce persistent inflammatory changes, propagating maladaptive immune responses across organ systems. Despite its significance, the exact mechanisms of maladaptive TRIM, its role in inter-organ communication, and its relevance to human health remain insufficiently explored.
My research has shown that sterile injuries induce epigenetic reprogramming in bone marrow hematopoietic stem and progenitor cells (HSPC), leading to systemic immune activation that exacerbates secondary organ dysfunction. Leveraging my expertise across established research fields (immunology, neuroscience, cardiology, clinical medicine), access to cutting-edge technologies including spatial multi-omics, and new translational models, I am uniquely positioned to address these challenges.
The project has four specific aims:
Aim 1: Characterize the epigenetic landscape of bone marrow niches in response to sterile tissue injury.
Aim 2: Identify disease- and compartment-specific characteristics of bone marrow alterations.
Aim 3: Investigate the causal role of maladaptive TRIM in secondary organ dysfunctions.
Aim 4: Assess the translational relevance of TRIM.
TRAINED will establish TRIM as a key pathomechanism in sterile tissue injuries, identifying key molecular and cellular targets that drive multimorbidity. By defining a detailed mechanistic framework, this project will lay the foundation for the development of novel therapies preventing maladaptive inter-organ communication in sterile injury.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine neurology stroke
- medical and health sciences clinical medicine cardiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
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