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Large-scale interactions mediating cognitive processes: Non-linear and non-separable

Objective

The human brain's cognitive abilities arise from complex interactions among highly interconnected brain areas. We have recently argued that interactions between oscillations at the same frequency (coherence-through-communication) cannot fully explain this coordination, due to the heterogeneity in cortical oscillation frequency and amplitude, as well as rapid cognitive state changes linked to aperiodic transients. Instead, we propose that non-linear interactions, which enable pattern recognition and integration beyond simple information relaying, are essential for understanding large-scale integration. NONLIN will investigate how non-linear mechanisms coordinate large-scale cortical networks and mediate cognitive and brain state changes, and will determine the non-separable nature of information integration, where combined influences of multiple regions on a target area cannot be decomposed into independent effects, counter to traditional modular views of cognition. To move beyond bi-variate, linear measures like coherence and Granger causality, NONLIN develops new mathematical methods to isolate and characterize non-linear and non-separable interactions, separating them from linear correlations caused by simple linear information relaying. Using large-scale intracranial electrophysiological data from humans and non-human primates, NONLIN will analyze how non-linear interactions reflect whole-brain anatomical connectivity and exhibit emergent properties distinct from the linear functional connectome. NONLIN tests whether active, alert states enhance non-linear, non-separable information integration, and whether cognitive processes, including attention, working memory, and perceptual binding, are primarily mediated by transient, broad-band influences and cross-frequency interactions driven by non-linear interactions. These findings will advance our understanding of cognition and impact the diagnosis and treatment of brain disorders and altered states of consciousness.

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Topic(s)

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Funding Scheme

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HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

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(opens in new window) ERC-2025-COG

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Host institution

STICHTING RADBOUD UNIVERSITEIT
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 000 000,00
Address
HOUTLAAN 4
6525 XZ Nijmegen
Netherlands

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 000 000,00

Beneficiaries (1)

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