Objective
Precise and faithful removal of non-coding introns from the precursors of messenger RNAs is critical for productive gene expression. This process is catalysed by the spliceosome - one of the cell’s most complex molecular machines. Aberrant splicing is responsible for numerous diseases, including neuropathies, developmental disorders and cancers. In the past decade, structural studies of the spliceosome have transformed the field by providing unprecedented insights into its fundamental mechanism of action. Despite this rapid progress, many aspects of splicing biology remain poorly understood. In particular, how is splicing regulated and how does the outcome of splicing depend on its interaction with other cellular components? To address this knowledge gap, the SPRING project was developed with the aim to provide insights into three fundamental aspects of the context-dependent splicing regulation in humans: 1) splicing quality control mechanisms; 2) coupling of the transcription and splicing machinery; 3) regulation through the interaction with the local environment in the native cellular context. These fundamental questions in gene expression biology will be addressed by employing state-of-the-art methods in structural and molecular cell biology, including native complexes purification, cryoEM/ET and correlative imaging. This project aims to bring groundbreaking insights into the molecular mechanisms of splicing regulation and has the potential to be transformative for the field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
02109 Warszawa
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.