Objective
Bacterial diarrhoeal diseases represent a significant global health burden, particularly in vulnerable populations such as young children. A large proportion of these cases can be attributed to Salmonella and Shigella species, which have been flagged by the WHO and CDC as bacterial families posing a serious public health threat due to the rise of multi-drug resistant strains. A deep understanding of how these pathogens cause disease and how our immune system responds to infections is essential for the development of novel therapies. Precise regulation of immune signalling and the integration of multiple signal transduction cascades are critical in the rapid establishment of an effective immune response. While canonical pathways linking microbial detection to transcriptional responses are well characterised, the molecular signals fine-tuning inflammatory signalling remain poorly understood. Our published and preliminary findings support the calcium-regulated kinase CaMKII as a modulator of inflammatory sensing, boosting immunity against enteric invasive bacteria. Thus, the CaMKII axis stands as an evolutionary conserved target for diverse pathogens seeking to evade host immunity. This proposal will (1) Determine the dynamics of CaMKII activation during infection and how it integrates with inflammatory signalling; (2) Define the immune regulatory functions of CaMKII signalling using animal models of infection; and (3) Identify and characterise pathogenic factors that antagonise CaMKII to evade immune detection. This research plan at the interface between host and pathogen will reveal new mechanisms of immune sensing and pathogenesis. This will identify biological targets for novel antimicrobial and host-directed therapies
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences public health epidemiology epidemics prevention
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.