Project description
Next-generation tumour models for personalised cancer care
Cancer research models often fail to accurately replicate human tumours. This makes testing new therapies difficult. Since some forms of this disease such as lung cancer and lymphoma behave differently in the body, it is hard to find one-size-fits-all solutions. Personalised treatments require more realistic models. Supported by the Marie Skłodowska-Curie Actions programme, the TUMORGPLAT project will create advanced patient-derived tumour organoids (PDTOs) that closely mimic real tumours. By recreating the tumour environment, the project will help test cutting-edge therapies, including immunotherapy and radiotherapy. The results will offer new hope for tailored cancer care.
Objective
We aim to establish a European network of experts in non-animal preclinical models to develop the next generation of patient-derived tumor organoids (PDTOs) for both solid and hematological cancers. To this end, we have selected non-small cell lung cancer as a model, given its high incidence, and chronic lymphocytic leukemia and follicular lymphoma as representative B cell malignancies.
These PDTOs will incorporate a novel, tissue-specific artificial extracellular matrix, created using tailored 3D biohybrid hydrogels designed to mimic the human tumor microenvironment (TME). By integrating patient-derived tumor, immune, and stromal cells, the PDTOs will closely replicate the complexity of the original tumors, which will be evaluated using a multi-technique approach, including comprehensive omics characterization.
Our ultimate goal is to establish a robust platform for testing innovative therapies—particularly radiotherapy and immunotherapy—within the framework of personalized medicine. Specifically, we will focus on adoptive cell therapies using CAR T and NK cells, neutron capture (radio)therapy, and their combination.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences health sciences personalized medicine
- medical and health sciences medical biotechnology cells technologies
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-SE-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 Madrid
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.