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A step forward for unraveling the immune mechanisms and tools for tuberculosis spectrum management

Description du projet

Des mécanismes immunitaires sur le spectre de la tuberculose

La tuberculose (TB) n’est pas une maladie uniforme, elle englobe un spectre de symptômes qui vont de l’infection latente sans symptômes aux stades subcliniques et à la maladie active. Comprendre l’interaction du système immunitaire avec Mycobacterium tuberculosis sur ce spectre est essentiel pour anticiper l’évolution de la maladie et développer des outils de diagnostic plus performants. Avec le soutien du programme Actions Marie Skłodowska-Curie, le projet TB-SPECTRUM réunira un consortium international pluridisciplinaire pour étudier les mécanismes immunitaires sous-jacents aux transitions du spectre de la tuberculose. Le principal objectif est d’identifier les biomarqueurs de la progression de la maladie, d’améliorer les capacités de recherche translationnelle et de stimuler l’innovation dans ce domaine.

Objectif

TB-SPECTRUM aims to strengthen international research collaboration among different sectors and disciplines, and to structure a network to perform high-quality, translational, and multidisciplinary research for (i) a better understanding of tuberculosis (TB) spectrum immune mechanisms; and (ii) increasing the capacities of the involved staff fostering training and networking activities, as well as increasing their inter-sectoral employability opportunities. Understanding the host-pathogen interactions in the different phases of the spectrum is fundamental for detecting biomarkers of disease progression that can lead to new diagnostic approaches for identifying those individuals with a high-risk of developing disease if infected or for detecting subclinical TB forms. However, it is still unknown which immunological mechanisms are involved in infection/disease progression. To unravel this knowledge gap, it is mandatory to develop collaborative research which combines different expertise in the TB field (clinics, diagnostics, treatment, clinical studies management, cellular/humoral immunology, genomics, and technology transfer, among others). For that purpose, a Consortium of nine academic and non-academic Institutions harboring TB-renowned experts has been constituted. This network is formed by specialists in the clinical management of active TB cases and their contacts (from high and low incident countries); experts in basic/applied science; and a small and medium-sized enterprise (SME) involved in the development of immune assays. Altogether, the proposed goals will be achieved through secondments among the different sectors, which will be extremely important for progressing to a better understanding of the requirements needed in TB management and control; and will expose participants to new research environments that will reinforce multidisciplinarity. Moreover, the interaction with an SME will improve knowledge transference skills, stimulating entrepreneurship.

Champ scientifique (EuroSciVoc)

Mots‑clés

Programme(s)

Thème(s)

Régime de financement

HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges

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Appel à propositions

(s’ouvre dans une nouvelle fenêtre) HORIZON-MSCA-2024-SE-01

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Coordinateur

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Contribution nette de l'UE
€ 260 520,00
Adresse
CTRA DE CANYET S/N
08916 Badalona Barcelona
Espagne
Région
Este Cataluña Barcelona
Type d’activité
Research Organisations
Liens
Coût total
Aucune donnée

Participants (6)

Partenaires (2)