Project description
Identifying optimal treatment pathways
Choosing the right drug is vital for patients and clinicians. Systematic reviews help ensure decisions are based on the best evidence. However, treatment adjustments, such as dosage changes or switching medications, often lack strong supporting evidence. With this in mind, the EU-funded PATH project will develop and test a framework to identify optimal treatment pathways. It will build a statistical model to compare different approaches and evaluate its real-world use. Focusing on schizophrenia, the project will analyse treatment switches, dosage increases and added therapies to understand their effects. The outcome will be a practical toolkit for healthcare providers, patients, and policymakers, with potential influence on drug development.
Objective
“What is the drug of choice for the given condition?” is the most important question raised by patients and clinicians at the point of care. The use of systematic reviews to answer this question, accompanied often with pairwise or network meta-analysis, ensures that decisions are informed by the best available evidence. However, in many healthcare areas we are moving towards the era of treatment pathways, in which not only a single treatment but a sequence of treatments can be the optimal choice for patients. Despite the important advances in methodology of evidence synthesis, treatment adaptations, such as modifying dose, switching, adding or discontinuing treatments are rarely informed by evidence. The overarching research aim of this project is to develop and test a framework for deriving the optimal treatment pathway. To this aim, I have set the following objectives: a) develop the statistical framework to compare alternative treatment pathways and b) evaluate the framework by developing methods to make it useful and applicable to clinical practice. I have devised the concept that treatment pathways can be seen as a combination of components, in which, however, sequence needs to be taken into account. As a first step, I will thus use component network meta-analysis. I will subsequently incorporate advances from clinical trials, dose-response, time-course models and prediction models, among others. I will develop PATH using as an example schizophrenia, where I will model treatment switching, increasing dose and/or adding treatment and will produce relative effects between all alternative treatment pathways. PATH will provide a much-needed methodological toolkit to healthcare practitioners, patients and policy makers, while it has the potential to have a profound impact on drug manufacturing; manufacturers can be informed by the position of similar drugs in the best treatment pathways, so that they can target their newly to be developed drugs accordingly.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2024-TALENTS-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
546 36 THESSALONIKI
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.