Objective
Epigenetic dysregulation is a key contributor to numerous major diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, underscoring the critical need for scalable and cost-effective profiling technologies. A central challenge in precision medicine is the heterogeneity in patient responses to treatment, which is influenced by inter-individual epigenetic variability. DNA methylation, a fundamental epigenetic modification, plays a central role in disease pathogenesis and therapeutic outcomes. However, existing methylation profiling methods, such as whole-genome bisulfite sequencing (WGBS) and affinity-based enrichment approaches, are hindered by high costs, technical complexity, and DNA degradation associated with harsh chemical treatments.
To overcome these limitations, we developed MeTLAND, an innovative enzyme-based DNA methylation profiling method that enables efficient and selective detection of methylated regions in a single-step reaction. This streamlined, single-step workflow significantly reduces sample processing time, degradation, and cost. Designed to be broadly compatible with established genomics platforms, MeTLAND also supports integration with other epigenomic assays, facilitating multimodal data generation. Its compatibility with bulk, single-cell, and spatial epigenomic applications further enhances its versatility. With the global epigenomics market valued at $17 billion, MeTLAND addresses the growing need for accessible, high-sensitivity methylation profiling, positioning it as a transformative tool for both research and clinical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.