Objective
Deep brain stimulation (DBS) is used to treat neurological and neuropsychiatric disorders. To date, DBS devices have been implanted in more than 300,000 patients worldwide. However, the efficacy of DBS therapy varies across patients, leaving a substantial number of patients without significant symptom alleviation. Optimizing therapeutic outcomes is highly desirable for the patients’ well-being as well as to reduce socio-economic burden of untreated disorders. One of the major impeding obstacles is the difficulty to precisely localize DBS targets in individual patient brains. Despite research into alternatives, the need for optimizing target localization for DBS remains unmet.
The recent discovery of a hitherto unreported neural oscillation, enabled by my previous ERC Starting Grant DirectThalamus, is a promising solution to these challenges. The novel oscillation is spatially confined to the proximity of established DBS targets and could thus be used as a functional marker to improve localization and reduce non-responder rates. Funding from the ERC Proof of Concept aims to support essential preclinical steps towards establishing a functional marker of DBS targets that is associated with superior clinical outcomes. Those include optimization of detection algorithms, exploration of alternative access routes to deep brain electrophysiology and evaluation of the functional marker in larger cohorts. The goal of the project is to finalize preclinical work and prepare the implementation and funding of a clinical trial with the goal to realize the approach in clinical routines.
By integrating cutting-edge neuroscience with medicine and fostering collaboration among researchers, clinicians and medical device specialists, the project aims to optimize therapy effectiveness, advance DBS technologies and pave the way for the next generation neuromodulation: personalized DBS treatment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-POC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.