Objective
Malaria remains a significant public health challenge in sub-Saharan Africa (SSA), accounting for approximately 263 million global malaria cases and 95% of malaria-related deaths in 2023. The increasing emergence of partial artemisinin resistance markers and poor adherence to current multi-day antimalarial regimens necessitate the development of novel, effective, and accessible treatments. WANECAM3 aims to address this challenge by developing a single-dose cure for uncomplicated falciparum malaria using next-generation, non-artemisinin drug combinations.
Building on the successes of WANECAM and WANECAM2, the WANECAM3 consortium, supported by new clinical trial partners, will conduct Phase 2 and Phase 3 clinical trials across SSA countries (Mali, Burkina Faso, Gabon, Uganda, Kenya, Ethiopia). The trials will evaluate the safety, efficacy, and transmission-blocking properties of novel drug combinations (KAE609, INE963, MMV533) in both adult and pediatric populations, with the ultimate goal of achieving a single-dose cure. An innovative trial platform study design will accelerate drug development by enabling adaptive trial methodologies to identify optimal treatment regimens.
The project includes generating clinical data to support the progression of a promising single-dose combination therapy towards regulatory approval. Additionally, WANECAM3 will strengthen research capacity in SSA by expanding clinical trial infrastructure, training researchers and healthcare professionals, and fostering long-term expertise in antimalarial drug development and resistance surveillance.
Beyond clinical impact, WANECAM3 will work closely with national and regional regulatory bodies to facilitate the rapid adoption of next-generation treatments. The introduction of a single-dose regimen has the potential to improve adherence, reduce transmission, and ease the burden on already strained health systems, ultimately accelerating progress towards malaria elimination in SSA and globally.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- medical and health sciences health sciences public health
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-JU-GH-EDCTP3-2025-01-two-stage
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1081 HV Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.