Objective
Drug-resistant tuberculosis (DR-TB) is a critical global health challenge, particularly in low- and middle-income countries where access to rapid and comprehensive diagnostic testing is limited. Early detection of resistance to first- and second-line TB drugs is critical; however, current WHO-approved low-complexity tools detect only rifampicin resistance, while testing for other drugs requires additional, often inaccessible methods. The rapid emergence of resistance to newer drugs like bedaquiline further limits treatment options, underscoring the urgent need for affordable, scalable, and rapid diagnostics that cover a broader range of drug resistance profiles.
The R2D2-xDRTB project tackles this challenge by accelerating the development, validation, and implementation of next-generation drug susceptibility tests (DSTs). Over 36 months, the project will: (1) conduct multi-centre clinical trials in two high-burden DR-TB countries (South Africa and Georgia) to assess the accuracy of novel DSTs, and (2) integrate multidisciplinary data—including usability, acceptability, feasibility, and cost-effectiveness evaluations—to guide further development and policy. This approach ensures that new diagnostics meet the needs of diverse healthcare systems and end-users while informing implementation strategies.
By leveraging adaptive trial designs, Bayesian analyses, and human factors assessments, R2D2-xDRTB will streamline the validation of both early- and late-stage diagnostic prototypes in parallel, facilitate comparisons, and offer a holistic assessment of the DSTs. The project prioritizes innovative, low-cost, accessible DST solutions to address gaps in resistance detection, improve treatment outcomes, and reduce the global burden of DR-TB. Paired with the capacity strengthening in DR-TB clinical trials, the project represents a critical step toward achieving equitable access to life-saving diagnostics and ending the DR-TB crisis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-JU-GH-EDCTP3-2025-04-two-stage
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69120 HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.