Objective
Every year, 1.5 to 2 million people are successfully treated for tuberculosis (TB) in sub-Saharan Africa (SSA). Of these, on average 10% (150,000 to 200,000 people) experience recurrent TB disease within two years. The underlying mechanisms are a combination of relapse and reinfection, however the precise determinants are poorly understood.
People with previous TB are missing in current TB guidelines and target product profiles. However, this vulnerable population is disproportionately responsible for many reported TB episodes and is already captured within health systems. This represents a blind spot in TB control. Addressing this underserved population provides a huge opportunity to avoid recurrence and related healthcare costs.
Recurrent TB can be prevented by secondary preventive TB therapy (sTPT), although data are limited. Through its integrated design, RECENT-TB will generate evidence on the clinical and cost-effectiveness of sTPT and its implementation context, on the predictive value of affordable screening tools and on the diagnostic performance of novel diagnostics to detect recurrent TB. This evidence will allow development of a personalised risk score and cost-effective risk-stratified algorithms to target sTPT to those who will benefit the most, which will be translated into policy recommendations.
RECENT-TB’s unique value proposition is that it will generate evidence to transform the management of recurrent TB in Africa through an innovative risk-stratification approach that will extend the use and improve the uptake of existing preventive, predictive and diagnostic interventions in this vulnerable and underserved population: people with previous TB. The ambition of RECENT-TB is to halve the rate of TB recurrence and thereby avert 75,000-100,000 recurrences yearly in SSA, leading to reduced morbidity, mortality and further transmission.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine pneumology tuberculosis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-JU-GH-EDCTP3-2025-04-two-stage
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1081 HV Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.