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Advancing Clinical Care and Equity through Scalable Solutions in Alzheimer’s Disease diagnosis and treatment

Project description

Advancing care and equity in Alzheimer’s disease diagnosis and treatment

The EU-funded ACCESS AD project comprises a pan-European partnership that aims to improve how Alzheimer’s disease is diagnosed/treated in everyday healthcare. It combines brain imaging, blood-based biomarkers, digital tools, multi-faceted treatment approaches, policy and ethical review, and patient-centred support to enable earlier diagnosis and effective care. Although new therapies can slow disease progression for some patients, healthcare systems are not yet prepared to deliver them at scale. Many people still experience long delays in diagnosis, unequal access to testing and shortages of specialist services, which contribute to growing health inequalities across Europe. ACCESS AD aims to implement cost-effective diagnostic solutions, digital decision support and integrated care pathways in real-world settings, supporting timely diagnosis, personalised interventions and continuous monitoring across EU healthcare systems.

Objective

Alzheimer’s disease (AD) is a growing public health challenge in Europe’s ageing population. While Disease Modifying Therapies (DMTs) bring new therapeutic potential, fragmented care pathways, unequal diagnostic access, and healthcare limitations threaten their effectiveness and scalability. The Access AD Project is a collaborative initiative that exemplifies the public-private partnership model, bringing together government agencies and private sector organizations to addresses this unmet need by translating advanced diagnostics and monitoring approaches—such as blood-based and imaging biomarkers, digital and AI tools—into coordinated, equitable, and scalable care across real-world clinical settings in Europe. The project aims to ensure that every individual with AD can access timely, personalized, and cost-effective care, regardless of geography or socioeconomic status. ACCESS-AD builds on local, national, and EU-level efforts to create an integrated, pan-European framework for optimized AD care. The project will achieve: 1) establish robust coordination and governance to ensure efficient delivery and stakeholder alignment; 2) connect and expand fragmented clinical and research data through a shared platform, linking registries and initiatives across Europe; 3) reduce diagnostic access barriers by improving standardized imaging, blood-based, and digital biomarkers for clinical use; 4) develop AI-driven tools to support personalized treatment decisions; 5) generate harmonized real-world evidence on DMTs and emerging therapies; 6) assess health-economic, regulatory, and patient-reported impacts; 7) engage patients, professionals, and policymakers to ensure adoption and sustainability.
Aligned with IHI Call 9.2 ACCESS-AD unites and engages diverse healthcare stakeholders and integrates needs and perspectives of individuals affected by dementia to deliver inclusive, connected, and personalized care centered around the AD patient. By translating innovation into real-world practice, the project will reduce inequalities, support health policy, and improve outcomes for AD patients across Europe.

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Programme(s)

Topic(s)

Funding Scheme

HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions

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Call for proposal

(opens in new window) HORIZON-JU-IHI-2025-09-single-stage

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Coordinator

STICHTING AMSTERDAM UMC
Net EU contribution
€ 3 215 155,20
Total cost
€ 3 557 975,00

Participants (33)

Partners (2)