Objective
Today, chronic lung, heart, and kidney diseases constitute a large proportion of chronic illness in Europe’s population, with nearly 85% of deaths in the EU due to chronic diseases. Guideline-directed medical therapy is evidence-based and the cornerstone of pharmacological therapy for patients with chronic illness. Yet, a large number of patients are not receiving all medications as recommended given the length and complexity of guidelines. The ambition of GUIDE-AI is to leverage generative AI to increase guideline adherence of chronically ill patients in Europe. GUIDE-AI will be developed as a blueprint on three indications: Chronic obstructive pulmonary disease, chronic heart failure, and chronic kidney disease. This setup can be expanded to other chronic diseases where clinical practice guidelines exist or be updated with the new guideline once published. GUIDE-AI has three objectives:
OBJ-A[people-centricity]: GUIDE-AI integrates the perspectives of patients, physicians, healthcare administrators, and payers, addressing both inpatient and outpatient care and covering the full treatment continuum—from diagnosis and therapy initiation to long-term monitoring and treatment adjustments.
OBJ-B [Innovate & Integrate]: GUIDE-AI computer scientists and clinicians will develop the technical set-up of the guideline navigators including benchmarking and red teaming on retrospective data.
OBJ-C [evaluate in real world]: GUIDE-AI will evaluate the guideline navigators in a real-world evaluation study in a 2-arms randomized design. The primary outcomes are (1) the percentage of guideline-conform therapies and (2) the number of patients whose medication changed after the LLM-intervention.
Taken together, GUIDE-AI is a public-private partnership uniquely positioned to bring together private partners with leading academic institutions to advance beyond existing solutions to increase guideline-directed medical therapy by employing generative AI, making the latest evidence actionable. The impact will be demonstrated across multiple diseases, sectors, countries and languages.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.7 - Innovative Health Initiative
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-JU-IHI-2025-09-single-stage
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10117 Berlin
Germany
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Participants (15)
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27100 Pavia
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27100 Pavia
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9713 GZ Groningen
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2000 Maribor
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51005 TARTU
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16816 Neuruppin
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CB2 0AA CAMBRIDGE
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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22763 Hamburg
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8152 Glattpark
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WC1A 1DG LONDON
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56072 KOBLENZ
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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40789 Monheim am Rhein
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62098 Tel Aviv
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40215 Dusseldorf
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00183 ROMA
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Partners (3)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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81675 Munchen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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20157 Milano
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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10783 Berlin
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