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EXIT-CVD

Objective

"EXIT-CVD aims to fundamentally transform cardiovascular disease (CVD) management by enabling early, personalized, and equitable interventions across the CVD continuum. Recognizing CVD as a dynamic progression, from risk factors to heart failure and premature death, EXIT-CVD identifies and operationalizes strategic ""exit points"" where disease trajectories can be disrupted. Through a multidisciplinary, public-private partnership involving academia, Medtech, pharma, SMEs, and patient organizations, the project will integrate state-of-the-art diagnostics (e.g. photon-counting CT, AI-enhanced wearables), digital monitoring, regenerative therapies, and advanced imaging-guided interventions. Innovations are embedded in a digitally enabled, FAIR-compliant data platform aligned with the European Health Data Space (EHDS), ensuring real-world scalability and regulatory readiness. EXIT-CVD rigorously applies implementation science through the frameworks RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) which evaluates interventions along five core dimensions relevant to health systems uptake, and PROCTOR (Implementation Outcomes Framework) which focuses on concrete metrics such as acceptability, feasibility, fidelity, and cost. Additionally, EXIT-CVD adopts an equity-by-design approach to overcome persistent health disparities. Clinical studies target early detection (e.g. wearable blood pressure and AI-Electrocardiogram monitoring), intermediate stratification (e.g. imaging-guided Percutaneous Coronary Intervention (PCI) with Photon-Counting Computed Tomography (PCCT)), and late-stage recovery (e.g. engineered heart muscle transplantation and minimally invasive cardiac surgery supported by mechanical circulatory devices). By co-creating with patients and systematically addressing socioeconomic, gender, and digital access gaps, EXIT-CVD envisions a future where heart disease is not a terminal continuum but a preventable and reversible condition. This project will deliver validated, sustainable, and equitable innovations, positioning Europe at the forefront of cardiovascular health transformation."

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-JU-IHI-2025-09-single-stage

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Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 601 956,92
Address
HANZEPLEIN 1
9713 GZ Groningen
Netherlands

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Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 601 956,93

Participants (42)

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