Objective
Escherichia coli is a bacterial model organism with broad applications in molecular genetics and is clinically the most significant cause of bacterial infections. Domesticated E. coli have been the subject of fundamental research on bacterial evolution and genetics for decades, yet we have limited understanding of the mechanisms regulating natural E. coli populations that near-universally colonise the human gut. Evidence points to the existence of strong equilibria of lineage prevalence and synchronised appearance of novel genotypes across host populations, yet how such equilibria emerge and are maintained remains unclear. ACES aims to fill this knowledge gap through a combination of innovative sampling frames and in vivo experiments with the latest long-read sequencing and analytical techniques, including targeted PacBio shotgun metagenomics and simulation-based modelling. These technological advances provide an opportunity to obtain a refined characterisation of all genomic variation occurring in an E. coli population, including gene content, capsular antigens, plasmidome and phageome. The main hypothesis of ACES is that key accessory genomic elements augment the genetic capabilities encoded by the core genome and together control the ecological and evolutionary success of individual genotypes over time. ACES will develop models to assess whether observed population equilibria arise as a consequence of the success strategies driven by the accessory elements. The knowledge generated by ACES will have broad implications for understanding bacterial ecology and evolution, and our approach will pave the way to similar studies outside of bacterial model organisms in the future. ACES will also facilitate future prediction of the consequences of population interventions, such as novel antibiotics, probiotics and vaccines, informing the development of new means to alleviate the ongoing global antibiotic resistance crisis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences ecology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences genetics genomes
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-ADG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
0313 Oslo
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.