Objective
Plants survive pathogen attack by rapidly reprogramming gene expression. Recent discoveries from my host lab revealed that cell-surface and intracellular immune systems act synergistically: intracellular immunity amplifies the strength and duration of cell-surface responses through precise regulation of defence genes. Yet, the molecular mechanism underlying this amplification remains unknown. The RISE project will test the hypothesis that RNA Polymerase II (Pol II), the central enzyme for gene transcription, is a key regulatory node in this synergy. I will 1) map Pol II transcriptional dynamics during combined immune activation using nascent RNA sequencing at single-nucleotide resolution; 2) identify phosphorylation events that fine-tune Pol II activity through data-independent-acquisition phospho-proteomics, focusing on its C-terminal domain phospho-dynamics that couple immune signals to transcription; and 3) integrate transcriptional and proteomic data into causal gene regulatory networks using time-aware algorithms constrained by prior biological knowledge. This multi-omics approach will generate high-resolution datasets and reusable pipelines to reveal how phosphorylation codes shape Pol II behaviour and enable stronger and longer-lasting immune programs. The project addresses Horizon Europe priorities by advancing understanding of plant resilience, contributing to open-science resources, and informing sustainable agriculture. It will also strengthen my technical, computational, and leadership skills. Building on my international research path from China to Germany and now to the Netherlands, the MSCA fellowship will enable me to mature into an independent researcher in plant molecular biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture sustainable agriculture
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2311 EZ Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.