Objective
Pancreatic cancer is a devastating disease with poor survival due to late diagnosis. Current imaging modalities fail to detect the disease early enough, even in high-risk individuals enrolled in structured surveillance programs. To improve outcomes, biomarkers must be developed that detect high-grade dysplasia, the final premalignant stage, before progression to incurable cancer. This ERC Advanced Grant proposal, PRECISE-PANC, aims to develop such biomarkers using a uniquely powerful biofluid: pancreatic juice.
The applicant coordinates the world’s largest longitudinal biobank of pancreatic juice from individuals at high familial risk of pancreatic cancer (CAPS cohort). Furthermore through this proposal juice will be collected from the major European centres surveilling high risk individuals providing unprecedented potential to validate a novel biomarker. Drawing from this cohort, the project will apply advanced molecular profiling, specifically cfDNA fragmentomics and O-glycomics, to identify biomarkers with the sensitivity and specificity required for clinical decision-making. These technologies, not yet applied in combination to pancreatic juice, offer unprecedented potential to detect early oncogenic transformation.
Through collaboration with leading international experts in fragmentomics, glycomics, and cancer screening, PRECISE-PANC will define the molecular landscape of pancreatic high-grade dysplasia. The ultimate aim is to shift screening for high-risk individuals from non-specific imaging to molecular detection, enabling curative surgery before invasive cancer develops.
This proposal is timely, feasible, and based on unique existing infrastructure. It holds potential to revolutionize pancreatic cancer screening, reduce unnecessary surgery, and save lives.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology pancreatic cancer
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.