Objective
Psychotic disorders are amongst the most debilitating psychiatric conditions, estimated to have a global lifetime prevalence of 3%. Unlike other challenges in biomedicine, psychiatric conditions such as psychosis are predominantly characterized by subjectively experienced symptoms (e.g. hallucinations). A promising approach has conceptualized hallucination-like percepts (HALIPs) as confidently reporting a stimulus that was not presented, providing a tractable model of hallucinations across humans and animals. However, recent findings suggest that commonly used methods to measure subjective experience may be confounded by decision biases unrelated to perception. This raises the critical question of whether HALIPs truly reflect perceptual distortions, or instead decisional strategies. The answer is crucial: if HALIPs are not perceptual, animal models and clinical trials based on them risk mischaracterise the mechanisms of hallucinations, ultimately undermining treatment development.
The MISHAPS project aims to resolve this issue by establishing whether HALIPs arise from altered perception and by comparing them to the neural signatures of subjective experience in humans. Using a novel behavioral paradigm that isolates perception from decision-making, I will: (I) determine the extent to which HALIPs are perceptual, (ii) examine the role of dopamine-related physiological signals in their occurrence, and (iii) identify the neural markers of HALIPs using magnetoencephalography. By clarifying the perceptual basis of hallucinatory experiences, MISHAPS will strengthen translational models of hallucinations, advance computational psychiatry, and provide a framework that can be leveraged in pharmaceutical research, for instance by offering objective and bias-resistant behavioural markers to evaluate the efficacy of drugs targeting hallucinatory symptoms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC1E 6BT LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.