Objective
Carbon neutrality is a central objective of the European Union, requiring breakthrough solutions to lower industrial CO and CO2 emissions. Bioconversion of C1 gases into valuable chemicals provides such a sustainable pathway, combining emission reduction with circular bioeconomy benefits, while ensuring safety, no secondary pollution, and mild operating conditions. Acetogenic microbes such as Clostridium aceticum fix C1 gases via the Wood-Ljungdahl pathway (WLP), efficiently converting CO and CO2 into acetyl-CoA, which is further transformed into acetic acid and ethanol. These intermediates serve as precursors for medium-chain carboxylic acids (MCCAs), bio-based chemicals that can replace petroleum-derived products. However, slow electron transfer and metabolic bottlenecks limit ethanol production. To overcome this, the C1Bio-Nano project addresses this by integrating C. aceticum with FeS-coated Shewanella oneidensis MR-1 in continuous stirred-tank reactors, enhancing interspecies electron transfer, NADH regeneration, and ethanol synthesis. Building on this approach, it will (O1) optimize the MR-1@FeS NP–C. aceticum coculture to achieve ethanol/acetate ratio >2 and >30% efficiency gain; (O2) elucidate electron transfer and NADH mechanisms using isotopic labeling, electrochemical analysis, and 13C tracing during a secondment at Dr. Vogt's lab (UFZ, Germany); (O3) convert ethanol and acetate into MCCAs with Clostridium kluyveri, aiming for >30% yield improvement and enhanced carbon recovery via controlled CO2 loading and ethanol/acetate ratios, supported by kinetic-metabolic modeling. This project will develop a mild-condition, FeS NP-assisted microbial system for scalable, selective carbon fixation and MCCAs production, equipping the fellow with advanced skills in microbial electron syntrophy, fermentation engineering, and isotopic tracer analysis, while generating results relevant to EU industrial carbon valorization and sustainable chemical production.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences environmental sciences pollution
- social sciences economics and business economics bioeconomy
- natural sciences chemical sciences organic chemistry alcohols
- engineering and technology nanotechnology nano-materials
- engineering and technology industrial biotechnology bioprocessing technologies fermentation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15001 La Coruna
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.