Objective
Flaviviruses such as Zika virus (ZIKV), dengue virus (DENV), Japanese encephalitis virus (JEV), and tick-borne encephalitis virus (TBEV) cause millions of infections each year and represent a growing global health threat. Climate change, human migration, and vector expansion are driving their spread into new regions, increasing the likelihood of sequential infections and cross-immunity. While congenital ZIKV infection has revealed the devastating impact of flaviviruses during pregnancy, the risks posed by other members, including TBEV, remain largely unexplored. This is of particular concern since TBEV is endemic across large parts of Europe and Asia, where vaccination is commonly recommended, raising important questions about how vaccine-induced immunity may influence responses to subsequent flavivirus infections. The FLAVIPREG project will specifically address these questions in the context of pregnancy, a unique immunological state where maternal tolerance must coexist with antiviral defense. It will investigate how prior TBEV infection or vaccination shapes maternal–fetal susceptibility to heterologous flavivirus infections, with a focus on immune mechanisms, placental transmission, and neurodevelopmental outcomes. Combining advanced mouse pregnancy models, immunoprofiling, single-cell transcriptomics, and high-resolution imaging, the project brings together complementary expertise in maternal–fetal immunology (Singapore) and arbovirology (Czech Republic). Outcomes will provide mechanistic insight into flavivirus pathogenesis during pregnancy and inform vaccination strategies to better protect maternal and neonatal health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases RNA viruses
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine obstetrics
- natural sciences earth and related environmental sciences atmospheric sciences climatology climatic changes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
601 77 Brno
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.