Objective
Compounds with sulfur functional groups are ubiquitous in medicinal chemistry, agrochemistry and beyond. Many of these important molecules are sulfones and sulfonamides, of which the sulfur atom is in the most stable oxidation state VI. Sulfoximines and sulfonimidamides are attained by replacing S=O bonds on these functional groups with S=N bonds. These aza-sulfur(VI) analogues are highly attractive due to extra modularity in N-substituents and manifestation of a sulfur stereocentre, unlocking a rich chemical space for further exploration of new drugs, agrochemicals and chiral reagents. To accelerate the development of aza-sulfur(VI) with S=N bonds as next-generation pharmacophores, modern studies in synthetic chemistry have led to new methods to access aza-sulfur(VI) compounds of various type with high efficiency and stereoselectivity. Compared to acyclic aza-sulfur(VI) compounds, cyclic aza-sulfur(VI) compounds are heavily underexplored in all applications, yet potentially of much greater value due to a more well-defined and controllable stereochemical framework. However, there exists no common strategy to access them, especially in the context of stereocontrol. The very few existing reports of stereoselective construction of cyclic aza-sulfur(VI) compounds are restricted to a specific class of attainable scaffold each. The proposed research aims to directly address this shortcoming by developing an efficient, common strategy to a broad range of cyclic aza-sulfur(VI) scaffolds from three very simple chemical components: a carboxylic acid, primary amine, and a commercially available sulfinylamine reagent previously explored in the Willis group. The synthetic approach will not use any harsh reagents or conditions, and should be fully amenable to both diastereoselective and enantioselective construction of the sulfur stereocentre. This strategy will enable access to new stereoenriched cyclic scaffolds for design of superior drugs, agrochemicals and chiral reagents.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.