Objective
Diaphragm dysfunction is highly prevalent in mechanically ventilated patients on the intensive care unit (ICU) and is strongly associated with weaning failure, prolonged ICU stay, and increased mortality. Remarkably, diaphragm dysfunction can develop within 24 hours of ICU admission, suggesting mechanisms beyond muscle disuse atrophy.
Based on preclinical evidence, I hypothesize that diaphragm blood flow impairment is a key contributor to early diaphragm dysfunction mediated by two mechanisms: (1) reduced diaphragm blood flow from mechanical compression of the diaphragmatic vasculature from increasing levels of positive end-expiratory pressure (PEEP) during mechanical ventilation, and (2) sepsis-induced impairment of diaphragm blood flow. However, no human data currently exist on diaphragm blood flow during mechanical ventilation or sepsis in the ICU, due to the lack of available techniques to measure it.
In the QUIVER project, I will address this critical gap by utilizing contrast-enhanced ultrasound, a novel bedside imaging technique, to quantify diaphragm blood flow. QUIVER has two objectives: (1) to determine PEEP-induced changes in diaphragm blood flow in healthy volunteers during non-invasive ventilation and in invasively ventilated ICU patients, and (2) to unravel the effects of sepsis on diaphragm blood flow, first in healthy volunteers using an established human endotoxemia model and subsequently in septic ICU patients during and after the acute septic phase. By integrating my expertise with my supervisor’s in intensive care medicine, advanced ultrasound imaging and respiratory (muscle) physiology, QUIVER will elucidate the impact of mechanical ventilation and sepsis on diaphragm blood flow in ICU patients. This approach has the potential to mitigate early diaphragm dysfunction in ICU patients by introducing real-time assessment of diaphragm blood flow into clinical practice, enabling personalized ventilator settings and hemodynamic management strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences basic medicine physiology
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 GA NIJMEGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.