Objective
Gene defects in DNA repair pathways represent a significant cause of inherited neurological disease. Though traditionally viewed as nuclear regulators of the DNA damage response (DDR), ATM and ATR also function in the cytoplasm, influencing the actin cytoskeleton and mechanical stress signaling. Mutations in cytoskeletal proteins can mimic DDR-related syndromes, suggesting a functional link between DNA repair and mechano-transduction. The Mech-ATM project investigates how ATM/ATR signaling integrates mechanical cues from the extracellular matrix (ECM) with genomic stability mechanisms, aiming to identify key phosphorylation targets within cytoskeletal networks and define how disruptions in tGene defects in the DNA repair pathway represent a significant cause of inherited neurological disease. Though traditionally viewed as nuclear regulators of the DNA damage response (DDR), ATM and ATR also function in the cytoplasm, influencing the actin cytoskeleton and mechanical stress signaling. Mutations in cytoskeletal proteins can mimic DDR-related syndromes, suggesting a functional link between DNA repair and mechano-transduction. The Mech-ATM project investigates how ATM/ATR signaling integrates mechanical cues from the extracellular matrix (ECM) with genomic stability mechanisms, aiming to identify key phosphorylation targets within cytoskeletal networks and define how disruptions of this pathway affect brain development. Recent findings implicate ECM stiffness as a modulator of cellular behavior, and environmental factors like microplastics may exacerbate mechanical dysregulation and DNA damage, particularly in genetically susceptible individuals. Using cerebral organoids and proteomic approaches, Mech-ATM will uncover how ATM/ATR-dependent mechano-transduction contributes to neurodevelopment. This work may reveal novel therapeutic targets for neurodevelopmental and neurodegenerative diseases, while highlighting the impact of environmental stressors on brain health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences earth and related environmental sciences environmental sciences pollution
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.