Project description
Reactive species in cold plasma jets for personalised treatments
Cold atmospheric plasma (CAP) jets are advanced tools in biomedicine, useful for non-invasive treatments and addressing antimicrobial resistance (AMR). They generate reactive species at room temperature. However, precise control in biological environments is challenging. Supported by the Marie Skłodowska-Curie Actions programme, the REPLAMED project will improve CAP jets for delivering reactive species to biological samples. By varying discharge parameters and gas flow, it will uncover mechanisms that influence species delivery, crucial for tackling biofilm-associated infections and AMR. The project will use advanced imaging and diagnostics to map these species and trace their transport in biofilms. Overall, the project advances CAP as a viable clinical tool for targeted treatments.
Objective
Cold atmospheric plasma (CAP) jets are at the forefront of next-generation biomedical technologies in a time of increasing antimicrobial resistance (AMR) and need for non-invasive medical treatments. Their ability to generate reactive oxygen and nitrogen based chemical species at room temperature makes them powerful tools for a wide range of applications, especially in the biomedical field. However, achieving precise control over the delivery of these reactive species in intricate biological environments remains a formidable challenge.
The proposed research aims to advance control of CAP jets for precise delivery of reactive species to biological samples. By systematically varying discharge parameters, gas flow, and nozzle geometries, this study seeks to map distinct bifurcation or stable regimes, unraveling the underlying physical mechanisms that govern species delivery. Particular attention will be given to how these regimes modulate flux, spatial distribution, and chemical composition of reactive species, which are critical for biomedical applications addressing biofilm-associated infections and AMR.
The interplay between flow-induced discharge topologies will be examined to determine their role in shaping species transport in the plasma jet. Advanced imaging techniques, along with quantitative diagnostics such as Laser-Induced Fluorescence (LIF) and Two-Photon Absorption Laser-Induced Fluorescence (TALIF), will be employed to map these species. To validate the accuracy and localization of reactive species delivery, advanced chemical probes will be employed to trace their transport pathways through biofilm surrogates and real-world biofilms. This approach lays the foundation for translational biomedical applications, with a focus on site-specific treatments targeting biofilm-associated infections. This proposal bridges plasma physics, fluid dynamics, and microbiology, advancing the knowledge needed to translate CAP into a clinically viable tool.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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(opens in new window) HORIZON-MSCA-2025-PF
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YO10 5DD YORK NORTH YORKSHIRE
United Kingdom
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