Objective
As humans age, the risk of genetic aberrations increases, particularly in rare populations of blood-cell-producing haematopoietic stem cells (HSCs). Mutations in HSCs can give rise to myeloproliferative neoplasms (MPNs), which are treatable in many cases with therapies such as interferon-α (IFNα). However, 1–20% of patients progress to secondary acute myeloid leukaemia (sAML), a disease associated with poor prognosis and high mortality. This transformation is often driven by high molecular risk (HMR) mutations and is further exacerbated by pro-inflammatory cytokine environments.
This proposal will address these challenges by developing novel murine models to study how specific combinations of co-occurring mutations interact to drive disease progression and transformation. Modelling will occur via a flexible genetic engineering pipeline that allows generation of multiple mutational combinations in HSCs from which MPN is initiated. Complementary profiling of cytokine networks will identify inflammatory drivers of pathology. Together, these approaches will provide mechanistic insights into the molecular and microenvironmental determinants of MPN progression to sAML.
The project will be hosted by leading experts in haematological malignancies: Dr Steven Lane at QIMR Berghofer (Australia, outgoing phase) and Dr. Florian Heidel at Hannover Medical School (MHH,Germany, return phase). The applicant will bring expertise in stem cell dynamics and molecular haematology while gaining advanced skills in preclinical modelling, bioinformatics, and translational haematology.
The fellowship will generate impactful publications, highly relevant to the haematological community and public, strengthen European excellence in blood cancer research, and reinforce the ERA by consolidating advanced expertise within Europe while fostering durable international collaborations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine hematology
- medical and health sciences clinical medicine oncology leukemia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
30625 Hannover
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.