Objective
SCOPE aims to quantitatively elucidate the role of substrate preorganization via chemically diverse weak interactions within the second coordination sphere (SCS), a phenomenon referred to as “substrate pre-freezing”, in modulating the reactivity and reaction outcome of C(sp3)-H bond oxidation by a bioinspired non-heme Fe(IV)=O complex. This study will provide mechanistic insight into substrate positioning effects in mononuclear iron oxygenases, a widespread enzyme superfamily central to numerous biological processes. By leveraging simplified biomimetic systems, SCOPE seeks to clarify long-standing questions regarding the structure-reactivity relationship in these enzymes and inform broader principles of catalytic efficiency. The findings may also prompt a critical reassessment of Menger’s “split-site” model of enzymatic catalysis and contribute to a more rational understanding of the design principles required for supramolecular bioinspired systems capable of performing late-stage functionalization. SCOPE is structured around three specific objectives that involve (1) synthesis and characterization of four test bench complexes followed by a quantitative analysis of substrate-complex binding interactions within the SCS. Dissecting the mechanistic role of substrate preorganization at the SCS level in (2) modulating reactivity during hydrogen atom transfer (HAT) and (3) the reaction outcome (hydroxyl rebound step) in C(sp3)-H bond oxidation. Overall, SCOPE will allow me to develop the skills and expertise necessary to establish myself as an independent researcher and a future organic chemistry professor in Europe. This fellowship will provide me with the unique opportunity to conduct cutting-edge research at the University of Basel, a leading technical institution, under the mentorship of Prof. Konrad Tiefenbacher, a rising expert in supramolecular chemistry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4051 Basel
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.