Objective
Multiple sclerosis (MS) is a complex condition, characterised by an aberrant immune response which triggers the destruction of myelin in the central nervous system. Clinical manifestations are of neurodegenerative nature, but it is an autoimmune condition driven by pathogenetic T and B cell responses. Follicular regulatory T cells (Tfr) are essential for controlling T cell-B cell interactions, and growing evidence suggests that their dysfunction is associated with several autoimmune conditions. Interestingly, Tfr function is impaired in people with MS, but the underlying cellular and molecular mechanisms and their contribution to disease pathogenesis and progression remains to be addressed.
This project aims at identifying the mechanisms responsible for the impaired function of Tfrs, contributing to exacerbated T cell-B cell interactions in people living with MS. I will dissect the extent and nature of Tfr dysfunctional phenotype, to identify disease modified signatures. Using this information, I will then modulate these targets and evaluate the impact on Tfr cell function. Ultimately, the use of an animal model of MS will allow me to ascertain the organismal impact of modulating the impaired pathways found in Tfr cells of people with MS, in disease recovery and progression.
Collectively, the results of this work will help identify the mechanisms underlying Tfr dysfunction, responsible for exacerbated T cell-B cell interactions in responses of people living with MS, with potential of becoming a biomarker and prognosis tool. Additionally, modulating the dysfunctional targets in Tfr cells, will allow me to understand the impact of the pathways in disease onset and progression, which can contribute to improved therapeutic targets and strategies.
Developing this project as a MSCA Postdoctoral Fellow will greatly enhance my scientific and intrapersonal skills, expand my professional network and strongly contribute to my independence as a researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.