Objective
The increase in antimicrobial resistant (AMR) pathogens colonising the gut is associated with an increase in morbidity, mortality rates and high health care costs. It is estimated that bacterial AMR was directly responsible for 1.14 million global deaths in 2021 and contributed to 4.71 million deaths. The resident microbiota confers protective mechanisms against AMR pathogens known as colonization resistance (CR). The role of the gut resident microbiome in providing CR against AMR pathogens has been demonstrated by our group and others. These mechanisms include competitive microbial-microbial interactions but also complex microbial-host interactions. The capacity of the resident microbiota to block pathogens is partially provided by blocking their access to nutrients (nutrients-mediated competition). Much less explored in the gut microbiome is the capacity of commensals to directly kill pathogens with bacterial weapons (toxin-mediated competition). This project will address strategies to clear AMR pathogens by harnessing the competitive ability of gut strains possessing weapons (toxins-mediated competition) and the ability to starve pathogens (nutrients-mediated competition). For this, we will use an innovative technology called gut-on-a-chip built with human colonic cells from patient biopsies combined with validation via other in vitro and in vivo experiments (germ-free mice). This project aims not only to find solutions against AMR pathogens but also to better understand and predict CR. CR is modulated by host and microbial factors, making it hard to track and understand changes. A gut-on-a chip technology, will allow us to study and predict host-microbe interactions in a controllable manner; but also understand how the host modulates these microbial interactions and how the gut structure and physiology affect the CR dynamics. A human based gut-on-a-chip technology could be used as a tool to discover and develop new microbiome-derived therapeutics to fight AMR.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences basic medicine physiology
- engineering and technology other engineering and technologies microtechnology organ on a chip
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.