Objective
According to the World Stroke Organization (WSO), stroke is the third-leading cause of death and disability worldwide, with an estimated total cost of €60 billion in Europe. The number of people living with stroke is estimated to increase of 27% within 2047. In the last years, an increased incidence of stroke was observed among younger population, due to exposure to emerging risk factors such as stress. The leading role of the gut microbiota in stroke outcome has been demonstrated by the pioneering works conducted by Dr. Benakis, supervisor at the host Institute for Stroke and Dementia (ISD), showing that microbiota can influence brain damage severity. During my Ph.D. I demonstrated that stress exposure leads to alteration in microbiota composition, resulting in the production and accumulation in the brain of the microbial-derived uremic toxin p-cresol, which has been associated with an increased incidence of ischemic stroke. However, there are currently no studies exploring the correlation between stress, microbiota, and stroke, leaving a great gap that could have substantial clinical implications. The MicroStress project aims to investigate, for the first time, the relationship between chronic stress and stroke through microbiota alteration, combining in vivo and molecular cutting-edge technologies including metabolomic and epigenetic assays. Moreover, this project proposes a therapeutic approach using synbiotic – a mixture of probiotic and prebiotic – to modify microbiota composition and ameliorate stroke outcome. The combination of Dr. Benakis’ expertise in the microbiota-immune system-stroke interaction and my experience in stress-microbiota research will be fundamental to closing this gap. The MicroStress project is a unique opportunity to acquire new scientific and transferable skills, essential for achieving the project’s objectives and advancing towards an independent research career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia
- medical and health sciences basic medicine neurology stroke
- natural sciences biological sciences microbiology
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.