Objective
Glioblastoma, the most aggressive primary brain cancer, remains incurable despite combination treatments involving surgery, chemotherapy and radiation, with a median survival of just over 14 months. The host lab recently demonstrated that multiple treatment modalities induce the formation of a fibrotic scar in the brain, a phenomenon observed in both preclinical mouse models and patient samples. This fibrotic scar can serve as a protective niche for dormant glioblastoma cells, supporting their persistence and resistance to therapy. Over time, these dormant cells reawaken, proliferate, invade into the brain parenchyma, and directly contribute to glioblastoma recurrence.
Critically, it remains unclear what drives the transition of glioblastoma cells – both into dormancy and subsequently to re-proliferate/recur – within the fibrotic scar. This project aims to uncover the key factors and molecular mechanisms that regulate these switches. To achieve this goal, I will employ two complementary, yet independent strategies: (1) a targeted candidate-driven approach to elucidate the role of specific extracellular/ cancer cell-extrinsic factors enriched in the fibrotic scar in regulating cellular dormancy, using cell and molecular biology techniques; and (2) an in vivo loss-of-function genetic screening approach, aimed at identifying novel cell-intrinsic modulators of dormancy in glioblastoma. Together, these complementary strategies will provide new mechanistic insights into fibrosis-mediated glioblastoma dormancy and escape. Ultimately, this research could identify new molecular targets to inform the development of more effective and durable therapies for glioblastoma.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.