Objective
The deep osteochondral defects affect millions of people worldwide and remain a challenge for orthopaedic surgeons. It causes a major impact on quality of life, affecting mobility, and poses a major economic burden on the healthcare system. The increasing demand for knee grafts is reflected in the growing market size. The available clinical strategies include surgical methods such as knee grafts, scaffolds of stem cells, and growth factors. However, these suffer from challenges of rejection, high cost, incomplete tissue formation, and provide short-term relief. Traditional biomaterials fail to mimic the bone-cartilage interface, exhibit poor tissue integration, lack signals to recruit cells, and don’t address disease progression and nerve signalling. Electromagnetic (EM) stimulation is a biologically free approach that restores the electrophysiology via neuromodulation for effective tissue repair. However, EM use is limited to toxic biomaterials, painful implantation, and low clinical efficacy at the site. Hence, there is an unmet need for an ideal biomaterial to solve these challenges. The Electro-Nervogel addresses these challenges and advances the field of bone-neuro engineering by developing and testing the safety and efficacy of a multifunctional, minimally invasive injectable hydrogel for osteochondral repair via neuromodulation. The project incorporates biodegradable and sustainable principles into biomaterial science, in line with the European mission Horizon 2020 of the European Green Deal and the UN Decade of healthy ageing. The Global Fellowship will be conducted in partnership with a renowned institute from a third country and the return phase to an associated country. The team is well-equipped with the skills and infrastructure required for the project. The researcher will gain skills that can enhance employability. The project will have societal, technological, and commercial potential as a novel treatment for critical defects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- engineering and technology industrial biotechnology biomaterials
- social sciences economics and business economics sustainable economy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NW1 OTU London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.