Objective
"The introduction of fluorine into molecular scaffolds, while rare in nature, is a valuable transformation in the field of synthetic organic chemistry. Approximately 20% of marketed pharmaceuticals and 50% of agrochemicals introduced in the last 30 years contain at least one fluorine atom. Furthermore, fluorinated compounds, particularly those incorporating fluorine-18, are essential in positron emission tomography (PET) imaging. While traditional fluorination relied on highly reactive agents like F2, modern strategies favor milder, more selective reagents such as Selectfluor and NFSI, though these still depend on F2 for their preparation. Nucleophilic fluorinations using fluoride ions offer a complementary, more sustainable approach, yet remains underdeveloped compared to electrophilic methods.
Building on this, our project aims to fully leverage fluorides as sustainable source of ""F""-atoms to (1) expand the scope of known accessible nucleophilic fluorination reactions of C-H bonds and (2) to develop new electrophilic fluorinating reagents which bypass the necessity of F2. To achieve aim 1 and 2 we will leverage aminoxyl-derivatives, such as TEMPO (tetramethyl-1-piperidinyloxy), bearing various steric and electronic substitutions in combination with electrochemical techniques. Particularly, the various aminoxyl derivatives will be electrochemically oxidized to the corresponding oxoammoniums, the key reactive species, which can either promote hydride transfer from C-H substrates (relevant to aim 1) or undergo nucleophilic attack by fluorides (relevant to aim 2) by modulating the electronic and steric properties. This research ultimate goal is to enable sustainable, metal-free electrochemical fluorination methods that bypass the need for F2, potentially transforming access to key fluorinated motifs in synthetic chemistry.
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Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.