Objective
Diabetes and obesity incidences are rising globally, yet precision medicine solutions remain scarce. The Greenlandic Inuit population carries a unique genetic background with increased diabetes risk, but type-2-diabetes (T2D) is substantially underdiagnosed due to distinct disease pathology and biomarker profiles. The proteome and microbiome provide powerful intermediate readouts of genetic regulation, disease mechanisms, environmental factors, and lifestyle. Both have been linked to T2D and obesity in general populations.
In the interdisciplinary ARCTIC project, I will integrate the unique genetic background of Greenlandic Inuit (n=4180) with their plasma proteomics, fecal metagenomics, anthropometric, biochemical, clinical, and health registry data. The project aims to uncover diagnostic and prognostic biomarkers as well as the causal pathways of T2D and obesity. By leveraging plasma proteomics (>1200 proteins, 4180 samples) and the first-ever human fecal metagenomic sequencing effort in Greenland (700 samples), I will identify circulating proteins and microbial features that predict disease and incidence. Using genotyping information, I will locate protein quantitative trait loci (pQTLs) and assess their genetic colocalization with obesity and T2D risk variants to identify causal proteins, genes, and pathways. By integrating individual-level plasma proteomics and fecal microbiome profiles with host genetics and clinical data, I will enhance our understanding of the host-microbe symbiosis mechanisms and their interplay in disease.
The ARCTIC project will help reduce inequity in clinical care by advancing precision medicine for T2D and obesity in the Greenlandic population. It will provide new therapeutic targets for both indigenous and global populations and enhance our understanding of the host–microbe interactions that drive disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences health sciences personalized medicine
- natural sciences biological sciences microbiology
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.