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Fetal Exposomics Modulated by placental Metabolism

Objective

Chemical exposures during pregnancy are a major global health concern, as even very low concentrations can disrupt fetal development and increase long-term disease risk. Current exposome studies, however, largely neglect the placenta, a biochemical gatekeeper that not only restricts but also metabolizes chemicals, potentially generating metabolites that are less, equally, or more toxic. FEMME (Fetal Exposomics Modulated by placental MEtabolism) will systematically integrate placental metabolism into exposome research by analyzing 300 paired maternal, placental, and cord blood samples from the INSULIN mother–child cohort. The project will (1) identify and characterize placental metabolites of up to 800 environmental chemicals, (2) integrate these metabolites into exposome-wide epidemiological models linking prenatal exposures to developmental outcomes, and (3) unravel maternal and environmental determinants of individual variability in placental metabolism. By combining my expertise in chemical metabolism with the world-class strengths in exposomics and epidemiology at IDAEA-CSIC, particularly that of Dr. Montse Marquès, FEMME will create a transformative framework for prenatal exposomics with the potential to advance chemical risk assessment and protect maternal and child health.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 194 074,56
Address
CALLE SERRANO 117
28006 MADRID
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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