Project description
Assessing real-world impact of advanced diabetes treatments
Diabetes affects over 10 % of adults. Despite advances in treatment, there is a need for global leadership in equitable diabetes health services and policy development. Supported by the Marie Skłodowska-Curie Actions programme, the QUART-DT project will assess the real-world effectiveness and fairness of advanced diabetes treatments across Japan, Ireland and the UK. It will evaluate the gap between clinical trials and everyday use, known as the ‘voltage drop’, and introduce an equitable scale-up index for fair access. Using various methods, the project will estimate health impacts and deliver outputs including open protocols and dashboards for policymakers. The fellowship will offer training in advanced pharmacoepidemiology and equity methods, focusing on societal benefits.
Objective
Diabetes affects >10% of adults QUART-DT (QUantifying uptake And Real-world impacT of Diabetes Treatments) will quantify real-world coverage and fairness of advanced diabetes treatments, including sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, and sensor-augmented insulin pump therapy, measure the gap between randomized controlled trials and effectiveness in routine care (“voltage drop”), and model population health impact across Japan, Ireland, and the United Kingdom using harmonised health data.
We will introduce two decision-ready indicators: an equitable scale-up index that summarises fair access, and a voltage-drop measure that compares matched effects from trials and real-world studies. The work will use the concentration index with the Erreygers correction for equity analysis, target-trial emulation with new-user, active-comparator designs, and state-transition modelling to estimate disability-adjusted life years and prevented events. Outputs will include open protocols, reusable analysis code, and concise dashboards and policy briefs for guideline developers and payers.
Training: The fellowship provides practical training in advanced pharmacoepidemiology (target-trial emulation and robustness diagnostics), equity methods, population-impact modelling, and natural-experiment designs, alongside transferable skills in research integrity, data governance and protection, communication, and project and budget management, structured through a career development plan.
Alignment and career objective: The project is international, interdisciplinary, and intersectoral, integrates open science and public and patient involvement, and targets societal benefit by showing who benefits, by how much, and under what delivery conditions. The fellowship will prepare the researcher to lead equity-focused diabetes health services and policy research and to contribute to data-driven guideline and policy development in Japan and internationally.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
D02 YN77 DUBLIN 2
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.