Objective
Psychotic disorders are among the top causes of global disability due to their early onset and poor clinical outcomes. Forty percent of patients show no improvement within the first year despite access to evidence-based treatments. Yet, clinical trajectories after psychosis onset remain highly heterogeneous and poorly understood. Structural and functional thalamocortical dysconnectivity is consistently observed in early-stage psychosis (EP), contributing to persistent symptoms and impaired functional recovery. Research has largely focused on single-modality connectivity features of the thalamus as a whole, neglecting the anatomical specificity of its nuclei in shaping structure-function brain networks and symptom domains. THALAMIND aims to identify clinically relevant nuclei-specific thalamocortical structure-function connectivity coupling (SFCC) along the psychosis continuum (subclinical/schizotypy, EP, chronic). Leveraging multimodal magnetic resonance imaging, THALAMIND will examine how deviations of functional brain signals from the underlying anatomical architecture inform symptom severity, functional impairment, and short- and long-term outcomes. Traditional approaches have primarily focused on static models of SFCC, failing to capture transient dynamic fluctuations in thalamocortical connectivity. This proposal integrates both static and dynamic graph-based connectivity measures to assess spatially and spectrally specific thalamocortical SFCC profiles underlying clinical heterogeneity. Using this state-of-the-art multimodal approach, the proposed research will determine whether altered signal propagation in specific thalamic circuits can inform psychosis physiopathology and outcome prediction in EP. By characterizing clinically relevant thalamocortical SFCC patterns, THALAMIND will enable neurobiologically informed patient stratification to develop personalized early treatment strategies, with the goal of improving functional recovery and reducing disability.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1211 Geneve
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.