Objective
Increase in soil salinity is a major agricultural threat worldwide, therefor investigating plant molecular mechanisms for mitigation of salt-induced stress is necessary and timely. Salt stress triggers extensive proteome remodelling to maintain cellular proteostasis, a process relying on selective proteolytic pathways such as autophagy, which recycles cellular components via double-membraned vesicles. Although autophagy is known to be crucial for plant salt-stress responses, the molecular mechanisms underlying its selective activation remain elusive. The proposed project, SALTS, aims to close this gap by elucidating the principles of selective autophagy initiation during salt stress. Central to this effort is the poorly characterized plant protein ATG11. Conserved in other model systems, ATG11 is essential for initiation of autophagosome formation and recruitment of selective autophagy receptors (SAR). This makes ATG11 a prime candidate to uncover how selective autophagy is orchestrated in plants. SALTS will pursue three objectives: (i) define how Arabidopsis thaliana ATG11 engages with autophagy components, unravelling the molecular binding modes thanks to gold-standard methods supported by the host labs; (ii) characterize the subcellular regulation of AtATG11 during salt stress and its role in SAR recruitment using advanced live-cell imaging facility from the host institute; and (iii) exploit ATG11’s central function to develop a novel proximity-labelling tool enabling unprecedented resolution of the selective autophagy proteome under stress. SALTS will close fundamental gaps in our understanding of plant autophagy, clarifying its contribution to stress resilience and creating an innovative approach to investigate this process. Altogether, SALTS will deliver essential insights into plant stress biology with impacts extending beyond plant science while being a springboard for my development as an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences botany
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1180 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.