Objective
Gastric (GC) and colorectal cancer (CRC) are major contributors to cancer-related deaths worldwide and current therapies lack efficacy. Thus, it is crucial to search for novel therapeutics to combat the increasing toll these cancers place on society globally. Glycosylation is the process by which complex carbohydrates (or glycans) are attached to lipids and proteins and is orchestrated by a suite of glycosyltransferases and glycosidases, collectively known as glycoenzymes. Glycosylation mediates a plethora of cellular processes such as cell-cell communication and cell adhesion andaberrant protein glycosylation is involved in cancer progression by influencing cell signalling, metastasis and immune evasion. Thus, glycosylation offers a largely overlooked class of biomolecules that hold promise as therapeutic targets. Taken together, this project aims to implement glycoanalytical approaches for the development of novel therapeutic strategies for GC and CRC treatment and reveal new insights into the roles of glycosylation in cancer biology. State-of-the-art analytical approaches based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) will be applied to develop comprehensive knowledge of the glycome and glycoproteome of GC and CRC cell lines, tissues and patient-derived organoids. The outputs from these comprehensive glycoprofiling exercises will reveal the key glycoenzymes to target with inhibitors and their therapeutic potential and mechanisms of action. Glycan biomarkers and glycoenzyme inhibitors will also be used in combination with currently approved therapeutic drugs for cancer such as monoclonal antibodies (e.g. Cetuximab) to evaluate combinatorial effects. Overall, this project will provide the most detailed and clinically relevant glycoprofiles for GC and CRC and will pioneer the application of these biomarkers in the GC and CRC therapeutic settings to reduce the global burden of these deadly cancers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology colorectal cancer
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4200-135 PORTO
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.