Objective
Staphylococcus aureus is a major human pathogen responsible for a wide range of infections, from mild skin abscesses to lifethreatening conditions such as sepsis, endocarditis, and pneumonia. It colonizes about a third of the human population and can cause infections in both hospital settings and the community. The emergence of antibiotic-resistant strains, particularly methicillinresistant S. aureus (MRSA), complicates treatment and increases healthcare costs. Alarmingly, vancomycin-resistant S. aureus (VRSA) and vancomycin-intermediate resistant S. aureus (VISA) have also been reported, leading to more severe infections and longer treatment durations.
The success of S. aureus as a pathogen is largely due to its wide array of virulence factors and its ability to develop antibiotic resistance. Regulation of these critical functions occurs at both transcriptional and post-transcriptional levels, involving mechanisms such as small-RNAs (sRNAs). sRNAs are small regulatory molecules that can quickly modulate gene expression by binding to messenger RNAs (mRNAs). Despite their potential significance, the role of sRNAs in S. aureus virulence and antibiotic resistance during human infection remains poorly understood. Most existing studies have been conducted under in vitro conditions that do not accurately mimic human physiological environments.
To address this knowledge gap, we propose to use RNA sequencing data from human-derived samples to identify and characterize sRNAs that are important during human infection. This approach will provide a more accurate representation of sRNA expression and function in vivo. We aim to uncover previously undiscovered sRNAs that contribute to the virulence and antibiotic resistance of S. aureus. Our findings will enhance the understanding of S. aureus pathogenesis and inform the development of novel therapeutic strategies to combat this pathogen.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69622 Villeurbanne Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.