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Perfusable 3D-Bioprinted Human Liver-on-a-Chip with Silk–dECM Bioink for Biopharmaceutics

Objective

LiverAid aims to develop a next-generation bioengineered human liver-on-chip platform to improve the predictability of drug toxicity testing and disease modeling. This system integrates advanced 3D bioprinting with smart hydrogels, patient-derived liver cells, and perfusable microfluidics to more accurately replicate the human liver microenvironment. By combining biofabrication with embedded sensors and real-time readouts, LiverAid will allow continuous monitoring of key physiological and biochemical markers, such as albumin production, urea synthesis, cytochrome P450 activity, and inflammatory responses. The platform will be validated against conventional 2D/3D models using known hepatotoxins and rescue agents. This project aligns with the EU’s goals for reducing animal testing and improving personalized medicine approaches. It will also provide the applicant with hands-on training in organ-on-chip engineering, biosensing, and ML-assisted data analysis at the host institution in Germany, further strengthening their academic career and European research integration.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 217 965,12
Address
FÜRSTENGRABEN 1
07743 JENA
Germany

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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