Objective
ZebraDC aims to establish the zebrafish as a tractable model for conventional dendritic cell (cDC) research and leverage its strengths to uncover conserved and non-canonical cDC functions across vertebrates. While mammalian cDCs are well defined into three subsets—cDC1, cDC2A, and cDC2B—emerging evidence suggests that these cells also engage in underexplored roles beyond adaptive immune priming, including interactions with the nervous system. By integrating comparative immunology, advanced imaging, gene editing, and transcriptomics across zebrafish, mouse, and human models, this proposal will: (1) define zebrafish dendritic cells at the transcriptional level and establish their bona fide identity as cDCs, (2) dissect their developmental origin and functional properties to align them with vertebrate counterparts, and (3) validate conserved non-canonical cDC functions that could reshape current paradigms in immunology. Preliminary data support the feasibility of this approach, including a novel zebrafish flt3 reporter line with high specificity for putative cDCs, enabling in vivo tracking and functional studies. By harnessing the unique experimental advantages of the zebrafish and complementing these findings with mammalian validation, this project will advance our understanding of the evolutionary foundations of cDC biology and redefine their functional landscape. Ultimately, it will provide critical insights into cDC-mediated regulation of immunity and beyond, with implications for vaccination, inflammation, cancer, and neuro-immune therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1400-038 LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.