Objective
GLYCODECD44 aims to elucidate, at atomic resolution, how distinct glycan species on CD44 drive recognition by galectins and selectins, and how this translates into functional outcomes in the context of breast and colon cancer. Defined CD44 glycoforms will be generated to elucidate how glycan composition and presentation within the full glycoprotein context, determines specific recognition by lectins, and to understand the role of aberrant glycosylation in cancer
Isotopically labelled CD44 ectodomains bearing chemically defined tumour-relevant N- and O-glycan motifs through glycoengineering and chemoenzymatic remodeling will be generated to deduce the molecular interfaces, dynamics, and affinities of CD44 binding to selected galectins and selectins by employing state-of-the-art NMR experiments, complemented with ITC and BLI. Finally, the way that molecular recognition features elucidated in vitro affect the nature of the interaction on the cell-surface will be revealed.
Moreover, solidly based on the scientific aspects, the action will offer Dr Padilla a deep knowledge on the power of interdisciplinary research, particularly focused on glycosciences. It will provide him synergic expertise in Molecular Recognition, Biological Chemistry, and Glycobiology, allowing him to gain a high level of research independence and capabilities and develop a set of soft skills. It will also allow him to participate in international collaborations and reinforce his research networks. Altogether, these elements will strengthen a solid long-term competitiveness, essential for his forthcoming scientific career. Simultaneously, the host lab will highly benefit from Dr Padilla’s experience on NMR of macromolecular receptors and biophysics, key for the development of the project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences biophysics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48160 DERIO VIZCAYA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.