Objective
PRODIGIO (PROton therapy DIfferentiable Gradient-based Inverse Optimization) aims to develop the first uncertainty-aware auto-planning framework for Intensity-Modulated Proton Therapy (IMPT).
This project addresses a critical gap in current treatment planning systems, which optimise only beam fluences while keeping orientations and energy layers fixed and manually chosen by the operator, and account for uncertainties through simplistic global margins. These limitations restrict plan quality, increase computation times, and lead to strong operator dependence.
At its core, PRODIGIO will develop a deep-learning dose engine trained on Monte Carlo simulations, capable of producing millisecond-accurate dose maps. Differentiable estimates of motion- and density-related uncertainties will be incorporated using advanced methods such as polynomial chaos expansion. This engine will be embedded in a novel optimisation pipeline where fluences, energies, and orientations are simultaneously optimised with gradient-based algorithms that explicitly account for uncertainties.
The project is highly interdisciplinary, positioned at the intersection of medical physics, numerical optimisation, and clinical practice. It involves three world-leading centres: the host institution (UniOvi), under the supervision of Pietro Vischia, an expert in differentiable optimisation and particle physics; a secondment at TU/e on differentiable uncertainty quantification; and a secondment at MAASTRO Clinic for clinical IMPT practice and validation.
In summary, PRODIGIO will deliver a significant impact on both the researcher’s career and on cancer care. On the one hand, it will provide extensive multidisciplinary training, placing the researcher in a leading position in the field. On the other, it will deliver the first uncertainty-aware, operator-independent auto-planning system for proton therapy, with the potential to transform radiotherapy treatment planning in Europe and worldwide.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
33003 OVIEDO
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.