Objective
Fractures in the craniofacial and alveolar regions are a significant health concern, with millions of cases reported each year. The standard treatment for these injuries is bone grafting, which is the second most common tissue transfer procedure worldwide, but it involves notable risks and limitations, such as donor site morbidity and limited availability. Bone tissue engineering (BTE) offers a promising alternative by using biomaterial scaffolds to stimulate regeneration. Traditionally, BTE has focused on recruiting progenitor cells and reducing immune responses; however, a recent paradigm shift recognizes the early immune system, particularly macrophages, as a crucial regulator of healing. Macrophages initially adopt a pro-inflammatory (M1) phenotype to start the healing process, then switch to an anti-inflammatory (M2) phenotype to support vascularization and bone formation. An improper switch can result in chronic inflammation and scaffold failure. A new strategy, immuno-driven bone regeneration, aims to leverage this regenerative capacity. While biochemical modifications are common, they can face stability issues and systemic side effects. The proposed research emphasizes a more reliable approach: applying physical modifications to a new class of injectable granular hydrogels. This innovative material will feature controlled 3D surface curvature, an underexplored yet highly promising method for influencing macrophage fate. The project will first test the hydrogels in vivo to evaluate their regenerative potential. The data collected will then be used to develop a physiologically relevant in vitro model, providing a detailed, mechanistic understanding of immune-driven bone healing. This innovative approach aims to provide a more reliable and less invasive treatment for bone defects, while also reducing the need for animal testing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.