Objective
Remembering fearful episodes is crucial for anticipating future threats. To this aim, some memories undergo consolidation, a process that selects and integrates important information into the existing knowledge base of the brain. Memory information is stored in specific subsets of neurons called engrams. As time elapses, memories undergo generalization, a useful process allowing related information to be incorporated into the original trace. However, excessive generalization becomes maladaptive when memory recall aberrantly occurs in conditions not related to the original event such as in Postraumatic Stress Disorder. Understanding how memories are generalized is of paramount importance for preventing and treating memory overgeneralization. Why do some fear memories degenerate into pathology? Can we predict which memories will overgeneralize? Can overgeneralization be corrected? Here, we aimed to use the mouse olfactory system to investigate the evolution of fear memory engrams. Indeed, the olfactory system offers a unique setting for the longitudinal observation and manipulation of memory engrams, as odors are processed by conserved neuronal maps in the olfactory bulbs. First, using calcium imaging visualization of individual divergence from the known common odor engram, we aim to define a cell code that can predict overgeneralization and, subsequently, the individual development of pathological memories. Furthermore, using a novel technique, FLiCRE, that allows permanent engram tagging at an unprecedented temporal precision, we aim to target odor-related fear memory engrams, and rectify overgeneralization by disassociating the neuronal engram of the traumatic experience from unrelated information. This proposal will uniquely dissect how memories are encoded in the olfactory system and provide a tool for understanding, predicting and improving traumatic memories.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.