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MELAnin-inspired radical architectures for Near-InfraRed-driven ultrafast photochemistry in water 

Project description

Melanin-inspired materials to drive reactions with sunlight

Nature’s own design often holds the key to solving complex challenges in technology. Inspired by melanin, the pigment that gives colour to skin and hair, the MELA-NIR project will create advanced materials that harness sunlight to drive chemical reactions in water. These synthetic melanin-based systems combine broad light absorption, stability in water and long radical lifetimes to drive chemical reactions, offering a non-toxic, scalable alternative to metal-based systems. With the support of the Marie Skłodowska-Curie Actions programme, the MELA-NIR project will combine near-infrared multidimensional spectroscopy to create scalable, non-toxic alternatives to traditional metal-based platforms, opening new doors for solar-powered chemical processes.

Objective

Harnessing solar energy for sustainable chemistry requires platforms with panchromatic absorption, extending into the near-infrared (NIR), and excited-state radicals that persist in biologically relevant aqueous media long enough to drive reactions. Yet no system combines both, leaving a “NIR photoredox gap” that limits green manufacturing, pollutant remediation, and biocompatible chemistry. MELA-NIR will close this gap by developing melanin-inspired radical architectures. Synthetic melanins uniquely combine broad absorption, aqueous stability, and radical lifetimes beyond milliseconds, offering scalable, non-toxic alternatives to scarce metal-based platforms while extending performance into the untapped NIR. MELA-NIR pursues three goals: (i) map radical formation from femtoseconds to seconds using ultrafast transient absorption and IR spectroscopy (WP1); (ii) engineer hydroquinone–quinone donor–acceptor systems and charge-transfer-active cofactors to enhance NIR activity (WP2); and (iii) benchmark optimized scaffolds for NIR-driven photoredox reactivity and antioxidant function in water (WP3). Together, these steps will establish design rules for light-tunable radical buffering and deliver proof-of-concept for green chemistry and redox biology. The fellowship provides interdisciplinary training in spectroscopy, materials chemistry, and photophysics. At Ohio State University with Prof. Bern Kohler, I will gain expertise in ultrafast IR and melanin synthesis, complementing my UV–visible ultrafast background. At Politecnico di Milano with Prof. Giulio Cerullo, I will apply advanced NIR multidimensional spectroscopy to assess reactivity. This two-way transfer will equip me to establish an independent European research line at the physics–chemistry interface. By enabling NIR-induced radical photochemistry in aqueous media, MELA-NIR will advance solar-to-chemical conversion, support the European Climate Law, and position Europe as a leader in sustainable photochemistry.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

POLITECNICO DI MILANO
Net EU contribution
€ 396 991,08
Address
PIAZZA LEONARDO DA VINCI 32
20133 Milano
Italy
Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
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Total cost
No data

Partners (1)