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Fungal Terpenoids as Next-Generation Biocontrol Agents and Phytovaccines

Project description

Sustainable crop protection agents

Global food security is increasingly threatened by climate change and the overuse of synthetic pesticides. The EU’s Green Deal and Farm to Fork strategy call for a significant reduction in agrochemicals, creating an urgent need for effective natural alternatives. Fungal terpenoids are potent bioactive compounds with promising crop protection properties. However, their high production cost limits their widespread use. With the support of the Marie Skłodowska-Curie Actions programme, the FUNgTERP project aims to develop an integrated biotechnology platform for the discovery and scalable production of these compounds from the fungus Clonostachys rosea. Researchers will establish how these molecules protect plants and modulate soil microbiomes, creating a pathway to commercialisation and supporting the transition to sustainable agriculture.

Objective

"Global food security faces critical challenges from climate change and unsustainable agricultural practices. The EU's Green Deal aims to significantly reduce synthetic agrochemicals. The FUNgTERP project offers an ecologically sound alternative using fungal terpenoids—potent, natural bioactive compounds currently inaccessible due to high production costs.

This project will dismantle this barrier by creating a pioneering, integrated biotechnological platform for the discovery, scalable production, and functional validation of these compounds. It centers on the fungus Clonostachys rosea, a world-renowned biological control agent. The project's timeliness is enhanced by the recent high-quality genome for C. rosea, which has transformed gene identification into a high-probability bioinformatic exercise.

The core innovation lies in establishing a causal link between purified fungal terpenoids and their dual impact on plant health: direct antagonism and the induction of systemic resistance. This approach introduces a novel ""ecological risk-culling"" strategy, ensuring that only compounds beneficial to the entire agricultural ecosystem are advanced. The project will also provide the first mechanistic insights into how these specific molecules modulate the soil microbiome.

FUNgTERP aims for transformative impact by delivering new molecular tools and production platforms. By breaking the economic barrier of high-value terpenoids, the project will create a clear path to commercialization through licensing or a spin-off company, an approach validated by companies like Isobionics/BASF. The project directly supports the EU’s ""Farm to Fork"" Strategy and the EU Mission ""A Soil Deal for Europe"" by providing tangible, ecological solutions."

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Topic(s)

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HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 202 125,12
Address
WELFENGARTEN 1
30167 Hannover
Germany

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Region
Niedersachsen Hannover Region Hannover
Activity type
Higher or Secondary Education Establishments
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Total cost

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